Synthesis of 2-azetidinones substituted quinoline derivative
نویسندگان
چکیده
منابع مشابه
Synthesis and biological activity of N-substituted-3-chloro-2-azetidinones.
2-Aminobenzothiazole-6-carboxylic acid (1), on condensation with chloroacetyl chloride yielded 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2), which on amination with hydrazine hydrate yielded in turn 2-(2-hydrazinoacetylamino)benzo-thiazole-6-carboxylic acid (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-{2-[N'-(arylidene)hydrazino]acetylami...
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2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. Following this method, a series of 3-pyrrole- substituted 2-azetidinones have been synthesized with a variet...
متن کاملSynthesis and characterization of some quinoline based azetidinones and thiazolidinones as antimicrobial agents
A series of potentially active quinoline based azetidinones and thiazolidinones analogues has been synthesized by simple and efficient synthetic protocol. The tetrazole nucleus formed from 2chloroquinoline-3-carbaldehyde using p-toluenesulphonic acid and sodium azide followed by reaction with various substituted amine to form the corrosponding schiff base intermediates. Attempt made to derive f...
متن کاملSynthesis and biological activities of new substituted thiazoline-quinoline derivatives.
5-Acyl-8-hydroxyquinoline-2-(3'-substituted-4'-aryl-2,3-dihydrothiazol-2'-ylidene)hydrazones, 5a-e to 10a-c, were prepared by the reaction of appropriate 5-acyl-8-hydroxyquinoline-4-substituted thiosemicarbazones 3a-e and phenacyl bromides 4a-e. Structures of the new compounds were verified on the basis of spectral and elemental analyses. Twenty-eight new compounds were tested for their possibl...
متن کاملNovel polycarbo-substituted alkyl (thieno[3,2-c]quinoline)-2-carboxylates: synthesis and cytotoxicity studies.
Direct one-pot base-promoted conjugate addition-elimination of 6,8-dibromo-4-chloroquinoline-3-carbaldehyde with methyl mercaptoacetate and subsequent cyclization afforded methyl [(6,8-dibromothieno[3,2-c]quinoline)]-2-carboxylate. The latter undergoes Suzuki-Miyaura cross-coupling with arylboronic acids to yield exclusively the corresponding alkyl [(6,8-diarylthieno[3,2-c]quinoline)]-2-carboxy...
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ژورنال
عنوان ژورنال: Journal of the Serbian Chemical Society
سال: 2013
ISSN: 0352-5139,1820-7421
DOI: 10.2298/jsc120617081m